產(chǎn)品名稱：PerCP-Cy5.5 anti-mouse CD26 (DPPIV, THAM) 100 ug 產(chǎn)品貨號：eBioscience 45-0261-82 產(chǎn)品規(guī)格：100 ug Anti-Mouse CD26 PerCP-Cy5.5 Also known as: Dipeptidyl Peptidase IV, DPPIV, DPP4, Clone: H194-112 (H194-112.12.4.4.5) RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 45-0261 Cat. No. Size 45-0261-80 25 ug 45-0261-82 100 ug Description: The monoclonal antibody H194-112 recognizes mouse CD26, a thymocyte-activating molecule (THAM). CD26 is a surface expressed and soluble ectoenzyme (dipeptidyl peptidase IV) that cleaves dipeptides from the amino terminus of proteins. In particular CD26 has been shown to cleave CXCL12, CCL22, neuropeptide Y and glucagon. CD26 is involved in adhesion, apoptosis, disease regulation, and engraftment. Expression is regulated during thymic development at the messenger RNA level. Additionally, CD26 protein is found on thymocytes, a percentage of resting B cells, stimulated B cells, NK cells and a percentage of resting and activated T cells and other epithelial cell types. On human cells more CD26 protein is found on Th2 cells. Functional CD26 is expressed on Sca-1+c-Kit+lin- cells. This expression has been shown to correlate with mobilization of progenitor cells. Inhibition of CD26 activity through a variety of compounds enhances allogenic stem cell homing and engraftment. This antibody is reported to have activating function.
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