產(chǎn)品名稱：Mouse Sonic Hedgehog (shh) Carrier-Free Recombinant Protein 500 ug 產(chǎn)品貨號(hào)：eBioscience 34-8671-85 產(chǎn)品規(guī)格：500 ug Mouse Sonic Hedgehog (SHH) Recombinant Protein Carrier-Free Also known as: SHH, HHG-1 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 34-8671 Cat. No. Size 34-8671-82 100 ug 34-8671-85 500 ug Description: Sonic Hedgehog (SHH) is a highly conserved protein that plays an important role in embryonic development. It is expressed in neural tissue, the gut, and areas of limb development and promotes differentiation and growth in a tissue-specific manner. SHH is synthesized as a 45-kDa precursor protein, which is then cleaved to generate the active 19-kDa N-terminus. SHH interacts with the Patched and Smoothened transmembrane receptors, leading to the activation of GLI family transcription factors. Disruption of any part of this pathway during embryogenesis is associated with birth defects ranging from mild to severe. In *****s, abnormal activation of the SHH pathway has been implicated in several forms of cancer.
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