產(chǎn)品名稱：Carrier-Free Recombinant Human G-CSF 500 ug 產(chǎn)品貨號(hào)：eBioscience 34-8523-85 產(chǎn)品規(guī)格：500 ug Human G-CSF Recombinant Protein Carrier-Free Also known as: Granulocyte Colony Stimulating Factor RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 34-8523 Cat. No. Size 34-8523-82 100 ug 34-8523-85 500 ug Description: Granulocyte Colony Stimulating Factor (G-CSF) is a member of the IL-6 cytokine family. It is 207 amino acids long with one glycosylation site and two disulfide bonds. G-CSF can be expressed by many different cell types including fibroblasts, endothelial cells, monocytes, macrophages and bone marrow stromal cells. Production of G-CSF is upregulated in response to infection and inflammatory mediators such as IL-1β, TNFα, and LPS. IL-17 has also been shown to regulate the production of G-CSF. The receptor for G-CSF is structurally similar to type I cytokine receptors. The receptor is expressed on both hematopoietic and non-hematopoietic cells. Within the hematopoietic cells, G-CSF receptor is expressed predominantly on cells of myeloid origin, including granulocytes and monocytes but not on erythrocytes, lymphocytes or eosinophils. G-CSF receptor activates the Jak/STAT signaling pathway. G-CSF activates and mobilizes granulocytic precursors from the bone marrow and supports the proliferation, activation and differentiation of neutrophils in the blood.
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