產品名稱：Carrier-free recombinant human RANTES, 500 ug 產品貨號：eBioscience 34-8970-85 產品規(guī)格：500 ug Human CCL5 (RANTES) Recombinant Protein Carrier-Free Also known as: CCL-5 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 34-8970 Cat. No. Size 34-8970-82 100 ug 34-8970-85 500 ug Description: RANTES (regulated on activation normal T cell expressed and secreted), or CCL5, is an 8 kDa monomeric protein that belongs to the CC- family of chemokines. The chemokines in this family share a common g-protein coupled receptor, CCR5, which they bind to through a conserved core region. CCR5 is also known to be the co-receptor through which the HIV virus enters the cell. This effect is blocked by the binding of RANTES to CCR5, making these proteins potential targets for HIV therapy. RANTES plays an important role in the immune response by initiating the recruitment of leukocytes to the site of inflammation. It is a chemoattractant for T cells, monocytes, and dendritic cells, and may increase the cytotoxicity and promote proliferation of NK cells. It is reported to be produced by fibroblasts, platelets, and T cells. RANTES is also involved in the progression and metastasis of some forms of cancer, and constitutive expression has been demonstrated in some malignant tumors. Human and mouse RANTES share 85% sequence homology and demonstrate cross-species activity.
滬公網安備 31011002002623號
