產(chǎn)品名稱：Rat IL-17A/F Recombinant Protein Carrier Free 500 ug 產(chǎn)品貨號(hào)：eBioscience 34-8217-85 產(chǎn)品規(guī)格：500 ug Rat IL-17AF Recombinant Protein Carrier-Free Also known as: Interleukin-17AF, IL-17A/F, IL17A/F RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 34-8217 Cat. No. Size 34-8217-82 100 ug 34-8217-85 500 ug Description: IL-17A and IL-17F are members of the IL-17 family of proinflammatory cytokines. They share 50% amino acid sequence homology, which is the highest within the group. Both cytokines exist as homodimers although the individual subunits from each protein can also associate into a heterodimer known as IL-17AF. Expression of IL-17A, F, and AF is most often associated with the Th17 subset of CD4+ T cells, but has also been observed in NKT cells and γδ T cells. They play an important role in the activation of neutrophils and induce inflammatory cytokine production in epithelial cells, endothelial cells, macrophages, and fibroblasts through NF-κB signaling. The heterodimer displays bioactivity intermediate to that of the two homodimers, with IL-17A being the most potent. IL-17AF and Th17 cells have been implicated in various autoimmune disorders, including rheumatoid arthritis, psoriasis, irritable bowel syndrome, and asthma.
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