產(chǎn)品名稱：Human CCL21 (6Ckine) Recombinant Protein Carrier-free, 500 ug 產(chǎn)品貨號：eBioscience 34-8214-85 產(chǎn)品規(guī)格：500 ug Human CCL21 (6CKine) Recombinant Protein Carrier-Free Also known as: C-C Motif Chemokine 21, Exodus-2 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 34-8214 Cat. No. Size 34-8214-82 100 ug 34-8214-85 500 ug Description: CCL21, also known as 6Ckine, is a member of the CC- subfamily of chemokines. It is most closely related to CCL19, with which it shares 32% amino acid sequence homology. CCL19 and CCL21 are expressed mainly by stromal cells in the T cell-rich zones of lymph nodes. They are critical mediators of the homeostatic trafficking of naïve T cells and activated dendritic cells into the secondary lymphoid organs. CCL19 and CCL21 also play a role in T cell priming and activation, as well as the recruitment of lymphocytes to inflamed tissue. Both proteins signal via the G protein-coupled receptor, CCR7, which is expressed on T cells and mature dendritic cells. Although CCL19 and CCL21 both exhibit the same affinity for CCR7, only the binding of CCL19 results in the desensitization and internalization of the receptor.
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