產(chǎn)品名稱：Carrier-Free Recombinant Rat IL-17A (Interleukin-17A, CTLA-8) 500 ug 產(chǎn)品貨號：eBioscience 34-8170-85 產(chǎn)品規(guī)格：500 ug Rat IL-17A Recombinant Protein Carrier-Free Also known as: Interleukin-17A, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8, IL17 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 34-8170 Cat. No. Size 34-8170-85 500 ug Description: Interleukin-17A (IL-17A, also known as CTLA-8 and IL-17) is a member of the IL-17 family of proinflammatory cytokines. It is most similar to IL-17F, another member of the family with which it shares 50% sequence homology. Both cytokines exist as homodimers and individual subunits from each protein can also associate into a heterodimer known as IL-17AF. Expression of IL-17A is most often associated with the Th17 subset of CD4+ T cells, but has also been observed in CD8+ T cells, γδ T cells, and neutrophils. IL-17A is important as a neutrophil activator, and it induces inflammatory cytokine production in epithelial cells, endothelial cells, and fibroblasts through NF-κB signaling. IL-17A and Th17 cells have been implicated in various autoimmune disorders.
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