產(chǎn)品名稱：Mouse IL-15R/IL-15 Complex Recombinant Protein Carrier-Free 500 ug 產(chǎn)品貨號(hào)：eBioscience 34-8152-85 產(chǎn)品規(guī)格：500 ug Mouse IL-15/IL-15R Complex Recombinant Protein Carrier-Free Also known as: Interleukin 15, IL15, IL-15 receptor, receptor/ligand complex RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 34-8152 Cat. No. Size 34-8152-82 100 ug 34-8152-85 500 ug Description: This recombinant protein is the heterocomplex of the mouse IL-15 linked to soluble IL-15 receptor alpha chain (sushi domain) via a GS linker. Interleukin 15 (IL-15) is a cytokine that stimulates T and NK cell proliferation and differentiation. IL-15 regulates macrophage proinflammatory and chemotactic protein production. In addition, it induces differentiation of monocytes towards dendritic cells. The receptor for IL-15 is a high affinity heterotrimeric receptor composed of IL-15Rα and 2 additional subunits of the IL-2 receptor (beta and gamma). Upon activation, the receptor complex signals via the Stat and JAK pathways. It has been reported that the soluble form of IL-15Rα corresponding to the entire extracellular domain, cleaved by MMP’s, behaves as a high affinity IL-15 antagonist, whereas the recombinant extracellular domain comprised of the sushi domain together with the ligand, IL-15, behaves as a potent agonist by enhancing binding of IL-15 to the receptor complex. In fact, this receptor-ligand complex has approximately 10-100 fold increased proliferative activity.
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