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產品名稱：Anti-Mouse Granzyme B (clone NGZB) PE-Cy7, 100 ug 產品貨號：eBioscience 25-8898-82 產品規(guī)格：100 ug Anti-Mouse Granzyme B PE-Cy7 Also known as: CGL1, CTLA-1 Clone: NGZB RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 25-8898 Cat. No. Size 25-8898-80 25 ug 25-8898-82 100 ug Description: This NGZB monoclonal antibody reacts with mouse Granzyme B, which is a member of the granzyme serine protease family. Granzyme B is found in the granules of cytotoxic T cells and NK cells. Granzyme B has also been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved has been identified as mannose 6-phosphate receptor. This receptor functions as a death receptor for Granzyme B during cytotoxic T cell-induced apoptosis. This NGZB monoclonal antibody does not crossreact to human Granzyme B nor is staining blocked with GB11, suggesting it recognizes a different epitope.
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