產(chǎn)品名稱：Anti-Human/Mouse T-bet (clone 4B10) PE-Cy7, 100 ug 產(chǎn)品貨號(hào)：eBioscience 25-5825-82 產(chǎn)品規(guī)格：100 ug Anti-Human/Mouse T-bet PE-Cy7 Also known as: Th1-specific T box transcription factor, T-box expressed in T cells Clone: eBio4B10 (4B10, 4-B10) RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 25-5825 Cat. No. Size 25-5825-80 25 ug 25-5825-82 100 ug Description: The eBio4B10 monoclonal antibody reacts with mouse and human T-bet. T-bet is a Th1-specific T-box transcription factor critical to the development of the Th1 CD4+ T cell lineage. This is known based on the observations that T-Bet deficient mice have impaired Th1 cell development, and that ectopic expression of T-Bet results in development skewed to the Th1 lineage. T-Bet expression is induced by the Th1 cytokine IFN gamma, and T-Bet also regulates the expression of IFN gamma, likely, at least in part, through the modification of DNA accessibility and histone remodeling. In addition to IFN gamma, T-Bet is also known to regulate the expression of IL-12R beta and IL-2. Moreover, T-Bet plays a role in class-switch recombination in B-cells.
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