產(chǎn)品名稱：Anti-Human Notch1 APC (MHN1-519) 100 tests 產(chǎn)品貨號：eBioscience 17-9889-42 產(chǎn)品規(guī)格：100 tests Anti-Human Notch1 APC Also known as: Notch-1, TAN1, Motch, Neurogenic locus notch homolog protein 1 Clone: MHN1-519 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 17-9889 Cat. No. Size 17-9889-41 25 tests 17-9889-42 100 tests Description: This MHN1-519 monoclonal antibody reacts with human Notch1, one of four members of the Notch family of receptors. Notch receptors are 300-kDa single-pass transmembrane proteins. While the extracellular domain contains numerous epidermal growth factor-like repeats for ligand binding, the intracellular domain is involved in cell signaling. Upon binding its membrane-bound ligand (either Delta or Jagged), the Notch receptor undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by γ-secretase. The second cleavage event releases the Notch intracellular domain (NICD), which subsequently translocates into the nucleus, heterodimerizes with the DNA-binding protein RBP-J, recruits co-activator molecules, and ultimately activates transcription. Notch 1 is expressed on thymocytes, bone marrow hematopoietic stem cells, T and NK cells. Lower Notch1 expression levels can be found on B cells and monocytes. Studies show that some subsets of T-cell acute lymphoblastic leukemia (T-ALL) arise due to Notch1 chromosomal translocation with the TCRβ gene, which results in the expression of constitutively active Notch1. This cell surface receptor is involved in T cell lineage commitment, thymocyte development, and Th2 differentiation. The MHN1-519 monoclonal antibody recognizes the extracellular domain of Notch1, and has also been reported to block Notch1 binding to Delta-like 4.
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