產(chǎn)品名稱：Anti-Human IL-8 APC (8CH) 100 tests 產(chǎn)品貨號：eBioscience 17-8088-42 產(chǎn)品規(guī)格：100 tests Anti-Human IL-8 APC Also known as: Interleukin-8, CXCL8, NAP-I Clone: 8CH RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 17-8088 Cat. No. Size 17-8088-41 25 tests 17-8088-42 100 tests Description: This 8CH monoclonal antibody reacts with human IL-8 (CXCL8), a pro-inflammatory CXC chemokine. It is synthesized as a 99 amino acid precursor protein that is further processed into one of four isoforms, with the most common being 72 or 77 amino acids in length. IL-8(77) is secreted primarily by endothelial cells and is thought to be a less potent neutrophil activator than the other forms. It is present at high levels during fetal development, where it mediates angiogenesis rather than inflammation. The predominant form present in *****s is IL-8(72), which is expressed by monocytes, macrophages, epithelial cells, and fibroblasts in response to inflammatory stimuli, environmental stress, and steroid hormones. IL-8(72) is essential for the activation and recruitment of neutrophils to sites of inflammation, and has also been found to influence T cell migration. Signaling occurs through the G-protein coupled receptors CXCR1 or CXCR2. IL-8 transcripts are often upregulated in tumors, and it is associated with tumor angiogenesis and metastasis.
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