產(chǎn)品名稱(chēng)：Anti-Human Syk APC (4D10.1) 100 tests 產(chǎn)品規(guī)格：eBioscience 17-6696-42 產(chǎn)品貨號(hào)：100 tests Anti-Human Syk APC Clone: 4D10.1 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 17-6696 Cat. No. Size 17-6696-41 25 tests 17-6696-42 100 tests Description: This 4D10.1 monoclonal antibody recognizes human Syk, a 72-kDa member of the Syk/ZAP-70 family of non-receptor protein tyrosine kinases. Syk is expressed most highly in B cells, with lower expression in immature thymocytes, mast cells, and platelets. Syk can also be detected in fibroblasts, epithelial cells, hepatocytes, endothelial cells, and neuronal cells. This protein is a major component of signaling cascades downstream of the B and T cell antigen receptors and plays an essential role in lymphocyte development. Upon recruitment to immunoreceptor tyrosine-based activation motifs (ITAMs) on the antigen receptors, Syk is activated by phosphorylation on multiple tyrosines. Once activated, Syk phosphorylates proteins such as phospholipase C gamma and BLNK/SLP-65. Finally, abnormal Syk expression has been linked to tumor cell migration and invasion in several cancers.
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