產(chǎn)品名稱：APC Mouse PIR-A/B (clone 10-1-PIR), 100 ug 產(chǎn)品規(guī)格：eBioscience 17-3101-82 產(chǎn)品貨號：100 ug Anti-Mouse PIR-A/B APC Also known as: PirA, PirB, PIR A, PIR-A, PIR B, PIR-B, PIR AB, PIR-AB, PIRAB Clone: 10-1-PIR RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 17-3101 Cat. No. Size 17-3101-80 25 ug 17-3101-82 100 ug Description: This 10-1-PIR monoclonal antibody reacts with mouse paired Ig-like receptors of activating (PIR)-A and -B. These cell surface glycoproteins, which contain six extracellular Ig-like domains with distinct transmembrane and cytoplasmic regions, are expressed together on B lymphocytes, dendritic cells, macrophages, granulocytes, platelets, and mast cells. However, expression of PIR-A/B has not been observed on T cells, NK cells, and erythrocytes. The PIR-A receptor interacts with signaling molecules containing immunoreceptor tyrosine-based activation motifs (ITAMs) which lead to its activating function. In contrast, the PIR-B receptor associates with proteins possessing immunoreceptor tyrosine-based inhibitory motifs (ITIMs); therefore, this receptor has been shown to have an inhibitory function. PIRs bind MHC class I to modulate cell signaling and homeostasis of the immune system. Moreover, PIR-B knockout mice have been shown to exhibit susceptibility to Salmonella infection. Crossblocking studies indicate that 10-1-PIR recognizes a different epitope from 6C1 (cat. no. 46-5978).
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