產(chǎn)品名稱：APC Human CD39 (clone eBioA1), 100 tests 產(chǎn)品貨號(hào)：eBioscience 17-0399-42 產(chǎn)品規(guī)格：100 tests Anti-Human CD39 APC Also known as: Entpd1, Entpd-1 Clone: eBioA1 (A1) RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 17-0399 Cat. No. Size 17-0399-41 25 tests 17-0399-42 100 tests Description: The eBioA1 monoclonal antibody reacts with human CD39 also known as ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) or NTPDase. CD39 is an integral membrane protein with two transmembrane domains and exists as a homotetramer. It is the most prominent ectoenzyme of the immune system. The function of CD39 is to effectively remove toxic extracellular ATP by converting it to ADP or AMP. CD39 is thought to work together with CD73 to hydrolyze ATP and has been well characterized on Langerhans cells. Expression of CD39 was originally identified on activated lymphocytes. Expression is also found on a subset of T cells, B cells and dendritic cells as well as weak staining on monocytes and granulocytes. Recently, CD39 and CD73 have been found on regulatory T cells (Treg). Expression of CD39 on Treg may facilitate their entry into inflamed areas where high levels of ATP are present. Expression of CD39 on Foxp3+CD4+ cells ranges from 25-45%.
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