產品名稱：APC human CD34 (clone 4H11), 100 tests 產品貨號：eBioscience 17-0349-42 產品規(guī)格：100 tests Anti-Human CD34 APC Also known as: Mucosialin, Class III epitope Clone: 4H11 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 17-0349 Cat. No. Size 17-0349-41 25 tests 17-0349-42 100 tests Description: The 4H11 monoclonal antibody reacts with human CD34, also known as mucosialin. CD34 belongs to a protein family which also includes endoglycan and podocalyxin. Members of this family are single pass transmembrane proteins with a heavily glycosylated extracellular and N-terminal mucin domain. CD34 was first identified as an antigen expressed on hematopoietic progenitors, and has since been extensively used as a marker to isolate cells capable of hematopoietic cell engraftment. In spite of this, the function of CD34 remains unresolved. In addition to expression on hematopoietic progenitors, CD34 is expressed on some populations of mesenchymal stem cells, tumor cell lines, and by vascular endothelia in the *****. Epitopes of CD34 have been assigned to three classes (class I, II or III) based on their differential sensitivity to enzymatic cleavage by neuraminidase, chymopapain, or O-glycoprotease. According to this analysis, the 4H11 antibody belongs to class III, indicating that it reacts with a protein epitope.
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