產(chǎn)品名稱：APC Human CD16 (clone eBioCB16), 100 tests 產(chǎn)品貨號：eBioscience 17-0168-42 產(chǎn)品規(guī)格：100 tests Anti-Human CD16 APC Also known as: Low Affinity IgG Receptor 3, FCGR3a, FCGR3, IGFR3 Clone: eBioCB16 (CB16) RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 17-0168 Cat. No. Size 17-0168-41 25 tests 17-0168-42 100 tests Description: The eBioCB16 monoclonal antibody recognizes CD16 (FcγRIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80 kDa. CD16 is represented by two similar genes, CD16A (FcγRIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (FcγRIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.
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