產(chǎn)品名稱：Anti-Human CD200 Receptor Functional Grade Purified (OX108) 500 ug 產(chǎn)品貨號：eBioscience 16-9201-85 產(chǎn)品規(guī)格：500 ug Anti-Human CD200 Receptor Functional Grade Purified Clone: OX108 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 16-9201 Cat. No. Size 16-9201-82 100 ug 16-9201-85 500 ug Description: The monoclonal antibody OX108 recognizes human CD200R also known as OX2. CD200R is an inhibitory receptor with a similar structure as its ligand, CD200, yet lacks an ITIM domain typically found in inhibitory receptors. Instead the CD200R cytoplasmic domain contains a novel phosphotyrosine binding domain, NPXY, which after binding SHIP inhibits ERK, JNK and MAPK p38 pathways. In activated macrophages signaling results in inhibition of TNFα secretion. Isoforms of CD200R have been identified and are thought to play a major role in differentiation, especially in regards to tolerogenic DCs. Expression is restricted to hematopoietic cells: myeloid cells (monocytes, macrophages, DCs, neutrophils, mast cells and basophils) and a subset of T lymphocytes as well as langerhans (LC) cells and dendritic epidermal T cells. The epitope of OX108 is thought to be near the binding site of CD200.
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