產(chǎn)品名稱：anti-mouse B7-DC (CD273) FG Purified TY25 500 ug 產(chǎn)品貨號(hào)：eBioscience 16-5986-85 產(chǎn)品規(guī)格：500 ug Anti-Mouse CD273 (B7-DC) Functional Grade Purified Also known as: B7DC, PD-L2, PDL-2, PDL2 Clone: TY25 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 16-5986 Cat. No. Size 16-5986-81 50 ug 16-5986-82 100 ug 16-5986-85 500 ug Description: The TY25 monoclonal antibody reacts with mouse B7-DC/PD-L2. B7-DC, a member of the B7 family, has a predicted molecular weight of ~25 kDa and belongs to the Ig superfamily. The mouse B7-DC has a short cytoplasmic tail (4aa). B7-DC is primarily expressed by sub-populations of dendritic cells, monocytes and macrophages. Although B7-DC has structural and sequence similarities to the B7 family, it does not bind CD28/CTLA-4, but binds PD-1. The interactions between PD-1 and B7-DC/PD-L2 have been reported to be involved in costimulation or suppression of T cell proliferation depending on state of cellular activation. TY25 is a useful tool to study the exact function of B7-DC/PD-L2 in APC/T cell interaction and to characterize the expression pattern of this molecule in mouse.
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