產(chǎn)品名稱：Functional grade Mouse Delta-like 1 (clone HMD1-5), 500 ug 產(chǎn)品貨號：eBioscience 16-5767-85 產(chǎn)品規(guī)格：500 ug Anti-Mouse DLL1 (delta-like 1) Functional Grade Purified Also known as: DL1 Clone: HMD1-5 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 16-5767 Cat. No. Size 16-5767-81 50 ug 16-5767-85 500 ug Description: The HMD1-5 monoclonal antibody reacts with mouse Delta-like 1, one of five type I transmembrane proteins that serves as a Notch receptor ligand. Upon binding the Notch receptor (e.g. Notch 1-4), Delta-like 1 undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by γ-secretase. The second cleavage event releases an intracellular fragment whose biological function remains controversial. Delta-like 1 is expressed by thymic stromal cells, as well as on macrophages, dendritic cells, and stromal cells in the spleen. This protein is also expressed in nonhematopoietic tissues such as the lung and brain. Delta-like 1 has been linked to B cell development and differentiation, especially marginal zone and plasma cells, regulation of splenic dendritic cells, and leukemogenesis. This monoclonal antibody has been reported to have neutralizing activity.
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