產(chǎn)品名稱：Functional grade Mouse TSLP (clone eBio28F12), 500 ug 產(chǎn)品貨號：eBioscience 16-5491-85 產(chǎn)品規(guī)格：500 ug Anti-Mouse TSLP Functional Grade Purified Also known as: thymic stromal derived lymphopoietin Clone: eBio28F12 (28F12) RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 16-5491 Cat. No. Size 16-5491-82 100 ug 16-5491-85 500 ug Description: The monoclonal antibody eBio28F12 reacts with and inhibits the bioactivity of mouse TSLP. Thymic Stromal-Derived Lymphopoetin (TSLP) was first identified in the tissue culture supernatant of a thymic stromal cell line as a growth factor capable of inducing proliferation and differentiation of pre-B cells. It was later found to be closely related to another stromal cytokine, IL-7, with which it shares overlapping functions. Along with its proliferative effects on B cells, TSLP induces dendritic cells to support the differentiation of naïve T cells towards the Th2 lineage and may also be involved in the development of CD4+CD25+ regulatory T cells. The receptor for TSLP is heterodimeric and shares one subunit, IL-7Rα, with IL-7 and other members of the family, while the TSLPR subunit is unique to TSLP. TSLP expression can be induced by a variety of inflammatory cytokines and TLR ligands. Expression is regulated by NF-κB and has been detected in epithelial cells, stromal cells, and basophils. Elevated levels of TSLP are associated with asthma and atopic dermatitis, which are both Th2-mediated inflammatory conditions. It is believed that chronic overexpression of TSLP may result in increased sensitivity to allergens, resulting in susceptibility to these conditions.
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