產(chǎn)品名稱：Anti-Human CD85d (ILT4) Functional Grade Purified (27D6) 500 ug 產(chǎn)品貨號：eBioscience 16-5148-85 產(chǎn)品規(guī)格：500 ug Anti-Human CD85d (ILT4) Functional Grade Purified Also known as: ILT-4, LIR2, LILRB2, MIR10 Clone: 27D6 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 16-5148 Cat. No. Size 16-5148-81 50 ug 16-5148-85 500 ug Description: The monoclonal antibody 27D6 recognizes the CD85d protein also known as ILT4, LIR-2. It is a member of the ILT (immunoglobulin-like transcript)/ LIR (leuokocyte Ig-like receptor) MIR (monocytes Ig-like receptor) family. CD85d is a 110 kDa single transmembrane receptor containing 3 Ig-like domains and a long cytoplasmic domain containing ITIMs (immunoreceptor tyrosine-based inhibitory motifs). Expression is confined to monocytes, macrophages and dendritic cells. The ligand for CD85d is non-classical class I HLA-G, -B and G1. Upon ligand binding, tyrosine phosphatase SHP-1 interacts with the ITIM. Interaction of HLA-G with ILT4/CD85d is thought to contribute to tolerance during fetal implantation. Additionally it is the levels of ILT3 and ILT4 on DCs that suggests a role in organ allograft rejection. The monoclonal antibody 27D6 has been shown to block binding of ligand (HLA-G tetramer).
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