產(chǎn)品名稱(chēng)：anti-human CD180 FG Purified MHR73-11 100 ug 產(chǎn)品貨號(hào)：eBioscience 16-1809-82 產(chǎn)品規(guī)格：100 ug Anti-Human CD180 (RP105) Functional Grade Purified Also known as: RP-105, Toll-like Receptor, TLR Family Clone: MHR73-11 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 16-1809 Cat. No. Size 16-1809-82 100 ug Description: The MHR73-11 monoclonal antibody reacts with human CD180 (RP105). This 105 kDa type I transmembrane molecule is a member of the TLR family of proteins characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. RP105 physically associates with another molecule called MD-1 and is expressed on B, monocytes/macrophages, and dendritic cells. Histological studies show that RP105 is expressed mainly on mature B cells in mantle zones, while germinal center cells are either dull or negative. The RP105/MD-1 complex in concert with TLR4 mediates B cell recognition and signaling of LPS. MHR73-11 activates B cells, leading to increases in cell size, expression of the costimulatory molecule CD80, and DNA synthesis. Moreover, ligation of RP105 protects B cells from irradiation- or dexamethasone-induced apoptosis. Thus, RP105 is a signal transduction molecule and plays a role in regulation of B cell growth and death. A significant proportion of circulating B cells in SLE patients is RP105 negative. Loss of RP105 is associated with B cell activation and increased disease activity in SLE patients.
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