產(chǎn)品名稱：Anti-Mouse CD172a (SIRP alpha) Functional Grade Purified (P84) 500 ug 產(chǎn)品貨號：eBioscience 16-1721-85 產(chǎn)品規(guī)格：500 ug Anti-Mouse CD172a (SIRP alpha) Functional Grade Purified Also known as: SHPS-1, Signal-regulatory protein alpha-1 Clone: P84 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 16-1721 Cat. No. Size 16-1721-81 50 ug 16-1721-85 500 ug Description: This P84 monoclonal antibody reacts with mouse CD172a, also known as signal regulatory protein a (SIRPa). This cell surface glycoprotein consists of three Ig-like extracellular domains and two cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The ITIM domains have been demonstrated to recruit and bind the Src homology 2 domain-containing phosphatases SHP-1 and SHP-2. CD172a is expressed on monocytes, macrophages, dendritic cells, but not on T and B lymphocytes. Moreover, neurons and other tissues of the central nervous system have also been shown to express CD172a. The integrin-associated protein CD47 is the extracellular ligand for CD172a. Studies show that CD172a is involved in dendritic cell-mediated T cell activation, neutrophil migration, and phagocytosis. This monoclonal antibody has been reported to have neutralizing activity.
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