產品名稱：anti-mouse CD160 FG Purified eBioCNX46-3 (CNX46-3) 500 ug 產品貨號：eBioscience 16-1601-85 產品規(guī)格：500 ug Anti-Mouse CD160 Functional Grade Purified Also known as: BY55 Clone: eBioCNX46-3 (CNX46-3) RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 16-1601 Cat. No. Size 16-1601-81 50 ug 16-1601-82 100 ug 16-1601-85 500 ug Description: CD160 is a glycosylphosphatidylinositol (GPI)-anchored Ig-like glycoprotein first identified on human lymphocytes with the monoclonal antibody BY55. In mice, CD160 is expressed on almost all (intestinal intraepithelial lymphocytes) iIELs, NKT cells, most TCRγδ T cells, few NK cells and a minor subset of CD8+ T cells. Murine CD160 has been shown to bind to a wide range of classical and non classical MHC class I molecules and regulate NK cell activation. In vitro, CD3 activation of murine CD8+ T cells increases the expression of CD160 and induces the release of soluble CD160 (sCD160). In human, CD160 mAb cross-linking triggers TNF alpha, IFN gamma and IL-6 cytokine production by peripheral blood NK cells and inhibits tube formation and induces apoptosis of endothelial cells. In mice, cross-linking of CD160 with the CNX46-3 antibody regulates NK cell activation both positively and negatively, depending on the stimulus.
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