產品名稱：anti-mouse CD152 (CTLA-4, CTLA4) FG Purified 9H10 500 ug 產品貨號：eBioscience 16-1521-85 產品規(guī)格：500 ug Anti-Mouse CD152 (CTLA-4) Functional Grade Purified Also known as: CTLA4, Ly-56 Clone: 9H10 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 16-1521 Cat. No. Size 16-1521-81 50 ug 16-1521-82 100 ug 16-1521-85 500 ug Description: The 9H10 monoclonal antibody reacts with mouse CD152, also known as the cytotoxic T lymphocyte antigen-4 (CTLA-4). CTLA-4, a protein with structural similarities to CD28, is expressed on activated T cells and binds the B7 family members, CD80 (B7-1) and CD86 (B7-2), with higher affinity than CD28 does. CTLA-4 and CD28 appear to deliver opposing signals to T cells: while CD28 is a potent costimulator, CTLA-4 restricts the progression of T cells to an activated state by inhibiting IL-2 secretion and cellular proliferation. The cytoplasmic portion of CTLA-4 contains ER retention motifs, resulting in a large proportion of newly synthesized CTLA-4 in response to TCR signaling to be localized intracellularly.
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