產品名稱：anti-mouse CD86 FG Purified PO3.1 1 mg 產品貨號：eBioscience 16-0861-86 產品規(guī)格：1 mg Anti-Mouse CD86 (B7-2) Functional Grade Purified Also known as: B70, Ly-58 Clone: PO3.1 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 16-0861 Cat. No. Size 16-0861-81 50 ug 16-0861-82 100 ug 16-0861-85 500 ug 16-0861-86 1 mg Description: The PO3.1 monoclonal antibody reacts with mouse CD86, an ~80 kDa surface receptor also known as B7-2. CD86 and CD80 are members of the B7 family of costimulatory molecules. CD86 is expressed at low level on B cells, macrophages, and dendritic cells and is upregulated on B cells through a variety of surface stimuli including the BCR complex, CD40 and some cytokine receptors. CD86 is also expressed by activated mouse T cells and thioglycolate-elicited peritoneal cells. In addition to CD80 (B7-1), CD86 is a counter-receptor for the T cell surface molecules CD28 and CD152 (CTLA-4). The interaction of CD86 with its ligands plays a critical role in T-B crosstalk, T cell costimulation, autoantibody production and Th2-mediated Ig production. The kinetics of upregulation of CD86 upon stimulation supports its major contribution during the primary phase of an immune response.
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