產(chǎn)品名稱：Anti-Human CD58 (LFA-3) FG Purified (TS2/9) 500 ug 產(chǎn)品貨號(hào)：eBioscience 16-0578-85 產(chǎn)品規(guī)格：500 ug Anti-Human CD58 (LFA-3) Functional Grade Purified Also known as: LFA3 Clone: TS2/9 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 16-0578 Cat. No. Size 16-0578-82 100 ug 16-0578-85 500 ug Description: The TS2/9 antibody recognizes human CD58, which is also known as Lymphocyte Associated Antigen-3 (LFA-3). CD58 exists both as a transmembrane protein as well as a GPI-linked extracellular protein. It has been shown that cells can express both forms concurrently. In addition, soluble CD58 has also been observed in serum, urine and synoval fluid of rheumatoid arthritis patients. CD58 is found on non-hematopoietic and most hematopoietic cells. Binding to its ligand CD2, which is present on T cells, initiates a signaling pathway which includes phosphorylation and results in release of cytokines. CD58 has been shown to be important in adhesion to various cell types, T cell activation, cytokine production and cytoxicity. The TS2/9 antibody has been reported to induce signaling events upon crosslinking. The epitope is in domain 1 of the immunoglobulin region.
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