產(chǎn)品名稱：Functional Grade anti-mouse CD41 (Clone MWReg30), 500 ug 產(chǎn)品貨號(hào)：eBioscience 16-0411-85 產(chǎn)品規(guī)格：500 ug Anti-Mouse CD41 Functional Grade Purified Also known as: fibrinogen receptor, gpIIb/IIIa, integrin alpha Iib Clone: eBioMWReg30 (MWReg30) RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 16-0411 Cat. No. Size 16-0411-82 100 ug 16-0411-85 500 ug Description: The eBioMWReg30 monoclonal antibody reacts with mouse CD41 (fibrinogen receptor, gpIIb, integrin alpha IIb). While initially thought to be expressed exclusively on the surface of platelets and megakaryocytes, it has been demonstrated that CD41 is also expressed on hematopoietic progenitors in the embryo, fetus and *****. CD41 associates with CD61 (gpIIIa, integrin beta III) to form a receptor which plays a major role in platelet function, including binding of several adhesion molecules such as fibrinogen, fibronectin and vitronectin. Recently, the SLAM-family markers, CD48 and CD150 have been used to reliably identify hematopoietic stem cells (HSC). Specifically, it was found that CD150+CD48- bone marrow cells were highly efficient in their ability to confer long-term multi-lineage reconstitution in irradiated mice. Furthermore, the efficiency of reconstitution was enhanced when HSCs were further enriched through the exclusion of CD41+ cells. Thus, the use of CD150+CD48-CD41- as an expression profile efficiently identifies hematopoietic stem cells.
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