產(chǎn)品名稱：Human IL-15 FG (Clone: ct2nu) 500 ug 產(chǎn)品貨號：eBioscience 16-0157-85 產(chǎn)品規(guī)格：500 ug Anti-Human IL-15 Functional Grade Purified Also known as: Interleukin-15, IL15 Clone: ct2nu RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 16-0157 Cat. No. Size 16-0157-82 100 ug 16-0157-85 500 ug Description: The ct2nu monoclonal antibody reacts with human IL-15 and neutralizes its bioactivity. IL-15, or IL-T, is a 14 kDa proinflammatory cytokine and member of the IL-2 family. It plays a role in the development and maturation of macrophages and dendritic cells, and is essential to the proliferation and survival of NK cells and CD8+ T cells. IL-15 is expressed by antigen-presenting cells, epithelial cells, and stromal cells. IL-15 activates the Jak/STAT pathway through its heterotrimeric receptor. Two subunits of this receptor, the β and γ chains, are shared with the rest of the family, while the α subunit is unique to IL-15. In mice, the α chain is required to chaperone IL-15 from the ER to secretion. This chaperoning is not necessary in humans, and free IL-15 is detectable in human biological samples. However, the receptor-cytokine complex has been indentified in humans and demonstrates agonistic activity several-fold higher than IL-15 alone.
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