產(chǎn)品名稱：anti-mouse CXCR4 (CD184, Fusin) Purified 2B11 100 ug 產(chǎn)品貨號：eBioscience 14-9991-82 產(chǎn)品規(guī)格：100 ug Anti-Mouse CD184 (CXCR4) Purified Also known as: C-X-C chemokine receptor type 4, Fusin, SDF-1 receptor Clone: 2B11 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-9991 Cat. No. Size 14-9991-82 100 ug Description: The 2B11 monoclonal antibody reacts with mouse and human CXCR4, also known as CD184, Fusin, LESTR, or HUMSTR. Fusin is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a coreceptor for X4 HIV-1 entry into CD4+ cells. In addition it has been shown to play a role in lymphocyte migration. The ligand for CXCR4 is SDF1. CXCR4 is required for maintenance of granulocyte progenitors in the bone marrow and essential for B cell development. Expression of CXCR4 is different between mice and human. In the thymus CXCR4 is restricted to CD4+CD8+ cells while in the spleen predominant expression is found on B lymphocytes. The monoclonal antibody 2B11 recognizes the amino terminus of CXCR4 and has been reported to have functional activity; it does not block SDF1a but causes internalization of the receptor.
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