產(chǎn)品名稱：anti-mouse PD-1 (CD279) Purified J43 500 ug 產(chǎn)品貨號(hào)：eBioscience 14-9985-85 產(chǎn)品規(guī)格：500 ug Anti-Mouse CD279 (PD-1) Purified Also known as: PD1 Clone: J43 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-9985 Cat. No. Size 14-9985-81 50 ug 14-9985-82 100 ug 14-9985-85 500 ug Description: The J43 monoclonal antibody reacts with mouse PD-1 (programmed death-1), a 55 kDa member of the Ig superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease in mice. PD-1 is expressed mainly on activated T and B lymphocytes. Two novel B7 Family members have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. It is reported that J43 inhibits the binding of mouse PD-L1-Ig and mouse PD-L2-Ig to PD-1/BHK transfected cells. When administrated in vivo, both intact and Fab of J43 are reported to enhance contact hypersensitivity and exacerbate acute GVHD similar to transfer of PD-1-deficient cells. Injection of J43 also exacerbates EAE and NOD diabetes as do specific antibodies to mouse PD-L1 and PD-L2.
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