產(chǎn)品名稱：anti-mouse AID Purified eBio961 100 ug 產(chǎn)品貨號：eBioscience 14-9974-82 產(chǎn)品規(guī)格：100 ug Anti-Mouse AID Purified (To Be Discontinued; refer to Cat. No. 14-5959) Also known as: Activation-induced cytidine deaminase Clone: eBio961 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-9974 Cat. No. Size 14-9974-80 25 ug 14-9974-82 100 ug Description: The eBio961 antibody reacts with mouse activation-induced cytidine deaminase (AID), a member of the cytidine deaminase family, which was cloned from a mouse B-cell lymphoma line induced by combined stimulation with transforming growth factor-beta, interleukin-4, and CD40 ligand. The human AID gene encodes a 198-amino acid protein containing a conserved cytidine deaminase motif. The human AID protein shares 92% amino acid identity with mouse AID. RT-PCR analysis of 15 human tissues detected strong expression of AID mRNA in lymph nodes and tonsils. Class switch recombination (CSR) is a region-specific DNA recombination reaction that replaces one immunoglobulin (Ig) heavy-chain constant region gene with another. This enables a single variable region gene to be used in conjunction with different downstream heavy-chain constant region genes, each having a unique biologic activity. AID, a putative RNA editing enzyme, is required for this action.
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