產(chǎn)品名稱：anti-mouse B7-DC (CD273) Purified 122 500 ug 產(chǎn)品貨號：eBioscience 14-9972-85 產(chǎn)品規(guī)格：500 ug Anti-Mouse CD273 (B7-DC) Purified Also known as: B7DC, PD-L2, PDL-2, PDL2 Clone: 122 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-9972 Cat. No. Size 14-9972-81 50 ug 14-9972-82 100 ug 14-9972-85 500 ug Description: The 122 monoclonal antibody reacts with mouse B7-DC, also known as PD-L2. B7-DC, a recently identified member of the B7 family, has a predicted molecular weight of approximately 25 kDa and belongs to the Ig superfamily. The mouse B7-DC has a short cytoplasmic tail (4aa). B7-DC is primarily expressed by subpopulations of dendritic cells and monocytes/macrophages in the mouse. Although B7-DC has structural and sequence similarities to the B7 family, it does not bind CD28/CTLA-4, rather it is a ligand for PD-1. The interactions between PD-1 and B7-DC/PD-L2 have been reported to be involved in costimulation or suppression of T cell proliferation depending on state of cellular activation. 122 has been demonstrated to block binding of TY25 (Cat. No. 14-5986), another mAb specific for mouse B7-DC.
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