產(chǎn)品名稱：Affinity Purified anti-human Caspase-8 100 ug 產(chǎn)品貨號：eBioscience 14-9934-82 產(chǎn)品規(guī)格：100 ug Anti-Human Caspase 8 Purified Also known as: Caspase8, CASP8 Clone: 1H10 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-9934 Cat. No. Size 14-9934-80 25 ug 14-9934-82 100 ug Description: The monoclonal antibody 1H10 recognizes human Caspase-8 also known as FLICE and MACH, a member of the cysteine-requiring aspartate protease family. Caspase-8 is an upstream caspase responsible for Fas and TNF-α mediated apoptosis. After activation of the Fas or TNF receptors by their ligands, the adaptor molecule FADD binds to the receptor and recruits caspase-8 to the membrane. The formation of this complex induces the cleavage and activation of caspase-8. The active form of caspase-8, made of a heterotetramer of p18 and p10, is released in the cytoplasm and activates downstream apoptotic proteases (caspase-3, -4, -6, -7, -9 and -10). Several (> 8) isoforms have been identified: 3 different pro-forms called Caspase-8a (55kDA), Caspase-8b (53kDa), and Caspase-8L which is procaspase-8 with an additional N-terminal extension of 59 aa. The 1H10 antibody recognizes the p55 and p53 proforms in addition to the p43 and p18 cleaved forms. Under reducing conditions, an additional band (possibly non-specific) around 35kDa may be present. Under nonreducing conditions, this band is absent.
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