產(chǎn)品名稱：anti-mouse Toll-like receptor 4/MD-2 - ACTIVATING Purified UT12 100 ug 產(chǎn)品貨號：eBioscience 14-9925-82 產(chǎn)品規(guī)格：100 ug Anti-Mouse TLR4/MD-2 Complex Purified (To Be Discontinued; refer to Cat. No. 14-9924) Also known as: TLR4/ MD-2, TLR-4/ MD2, toll-like receptor MD2 complex Clone: UT12 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-9925 Cat. No. Size 14-9925-81 50 ug 14-9925-82 100 ug Description: The UT12 monoclonal antibody was generated against BaF3 cells overexpressing mouse TLR4 and reacts with the mouse Toll-like receptor 4 (TLR4)/MD-2 complex. To date, at least twelve members of the Toll family have been identified. This family of type I transmembrane protein is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. Two of these receptors, TLR2 and TLR4, are pattern recognition receptors and signaling molecules in response to bacterial lipoproteins and have been implicated in innate immunity and inflammation. TLR4 physically associates with another molecule called MD-2, and together with CD14, this complex is responsible for LPS recognition and signaling. TLR4, which is approximately 100 kDa, is expressed by myeloid lineage cells.
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