產品名稱：Purified mouse/human Pax5 (clone 1H9), 100 ug 產品貨號：eBioscience 14-9918-82 產品規(guī)格：100 ug Anti-Human/Mouse Pax5 Purified Also known as: Pax-5 Clone: 1H9 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-9918 Cat. No. Size 14-9918-80 25 ug 14-9918-82 100 ug Description: The monoclonal antibody 1H9 recognizes both mouse and human Pax5. Pax5, also known as BSAP (B cell specific activator protein), is a member of the paired box (pax) family of transcription factors. Pax5 is the only member of the pax family of transcription factors that is expressed in hematopoietic cells. During embryogenesis, Pax5 is transiently expressed in the brain of mice and in the mesencephalon and spinal cord of humans. Its expression is upregulated early in B cell development at the time of B cell commitment and is maintained throughout most subsequent stages. Suppression of Pax5 is essential for expression of Blimp-1 and the terminal differentiation of plasma cells. In the spleen, expression of Pax5 is higher in marginal zone B cells (B220+ CD21high CD23low) than in other B cells, especially the transition 1 stage (B220+ CD21- CD23-). In addition to its role in B cell development, Pax5 also affects VH-DJH heavy chain recombination as well as influencing the expression of many other B and non-B cell related proteins. Pax5 expression is correlated with many neoplasms. In diffuse large B cell lymphomas (DLBCL) and non-Hodgkin lymphomas Pax5 is often mutated while in B-cell ALL, expression levels are high. Additionally, translocation with elastin, IGH, ETV6, FOXP1, and EVI3 have been identified. eBioscience recommends that the Foxp3 Buffers (cat. 00-5521) be used for optimal results when using this antibody for intracellular staining and flow cytometric analysis.
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