產(chǎn)品名稱：Anti-Human SLAM-associated protein Purified (10C4-SAP) 100 ug 產(chǎn)品貨號：eBioscience 14-9888-82 產(chǎn)品規(guī)格：100 ug Anti-Human SAP (SLAM-Associated Protein) Purified Also known as: T-cell signal transduction molecule SAP, SH2D1A, DSHP, SAP Clone: 10C4.2 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-9888 Cat. No. Size 14-9888-80 25 ug 14-9888-82 100 ug Description: This 10C4.2 monoclonal antibody reacts with human SLAM-associated protein (SAP). Upon SLAM receptor ligation, this 16-kDa SH2 domain-containing adaptor protein recruits Fyn tyrosine kinase, which phosphorylates the receptor to activate downstream signaling events. SAP is expressed in T, NK, and NKT cells, as well as eosinophils and platelets. This protein has also been detected in B cells and tumor cell lines such as Jurkat and Raji. Studies demonstrate that SAP expression in T follicular helper cells is required for germinal center formation. Moreover, this protein is involved in NKT cell development, Th1/Th2 differentiation, and controlling NK cytotoxicity. The role of SAP in B cells, however, is currently under investigation. Finally, deletion of the gene encoding SAP, SH2D1A, results in X-linked lymphoproliferative disease in humans.
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