產(chǎn)品名稱(chēng)：anti-human CD230 (Prion protein) Purified 4D5 100 ug 產(chǎn)品貨號(hào)：eBioscience 14-9230-82 產(chǎn)品規(guī)格：100 ug Anti-Human CD230 (PrP) Purified Also known as: Major Prion protein, PrP, PRNP Clone: 4D5 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-9230 Cat. No. Size 14-9230-80 25 ug 14-9230-82 100 ug Description: CD230 (prion protein; PrPC) is a 35 kD glycoprotein, attached to the cell surface via a GPI-anchor. While the function of CD230 is unclear, prion protein has been the focus of research based on its involvement in transmissible spongiform encephalopathies (TSE), including Creutzfeld-Jakob disease in humans. CD230 undergoes a conformational change in which the cellular PrPC form is converted to the scrapie PrPSc form. This conversion is essential for the infectiousness of prion-based diseases. CD230 is predominantly expressed on the surface of lymphocytes and monocytes, with weak expression on granulocytes and erythrocytes. In platelets, CD230 is expressed primarily intracellularly, and is upregulated to the surface upon activation.
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