產(chǎn)品名稱：anti-mouse / human / rat TIRAP Purified Polyclonal 50 ug 產(chǎn)品貨號(hào)：eBioscience 14-9058-81 產(chǎn)品規(guī)格：50 ug Anti-TIRAP Purified Also known as: TIR Toll-interleukin 1 receptor Clone: Polyclonal RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-9058 Cat. No. Size 14-9058-63 10 ug 14-9058-81 50 ug Description: The polyclonal antibody reacts with human, mouse, and rat Toll-interleukin 1 receptor (TIR) domain-containing adapter protein, TIRAP, and was generated using 15 amino acid residues near the C-terminus of mouse TIRAP. TIRAP, a signaling adapter molecule also known as myeloid differentiation protein 88 adapter-like (Mal) is involved in the signaling pathway of TLR4. TIRAP-deficient mice respond normally to the TLR5, TLR7 and TLR9 ligands, as well as to IL-1 and IL-18, but have defects in cytokine production and in activation of the nuclear factor NF-kappaB and mitogen-activated protein kinases in response to lipopolysaccharide, a ligand for TLR4. In addition, TIRAP-deficient mice are also impaired in their responses to ligands for TLR2, TLR1 and TLR6. Immunoblotting with this antibody gives a MW of ~35kDa in human heart lysate.
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