產(chǎn)品名稱：anti-human Toll-like receptor 2 (CD282) Purified TL2.3 100 ug 產(chǎn)品貨號：eBioscience 14-9029-82 產(chǎn)品規(guī)格：100 ug Anti-Human CD282 (TLR2) Purified Also known as: toll-like receptor 2 Clone: TL2.3 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-9029 Cat. No. Size 14-9029-82 100 ug 14-9029-80 25 ug Description: The TL2.3 monoclonal antibody reacts with human Toll-like receptor 2 (TLR2). To date, at least twelve members of the Toll family have been identified in human. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. Two of these receptors, TLR2 and TLR4, are pattern recognition receptors and signaling molecules in response to bacterial lipoproteins and have been implicated in innate immunity and inflammation. TLR2 is expressed by peripheral blood monocytes and is responsible for distinguishing different pathogens. TL2.1 and TL2.3, reported as blocking antibodies, have been used to study the role of TLR2 as a pattern recognition receptor in microbial lipoprotein/lipopeptide induced cytokine production from human peripheral blood mononuclear cells. TL2.3 has been reported to recognize a different epitope than TL2.1 and to work better for detection of TLR2 by immunohistochemistry. TL2.1 and its directly fluorochrome conjugates are more efficient for detection of human TLR2 by flow cytometric analysis.
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