產(chǎn)品名稱：anti-human Fn14/TWEAK Receptor (CD266) Purified ITEM-1 100 ug 產(chǎn)品貨號：eBioscience 14-9019-82 產(chǎn)品規(guī)格：100 ug Anti-Human CD266 (TWEAK Receptor) Purified Also known as: TNFRSF12A , TWEAKR, Fibroblast growth factor-inducible 14, Fn14 Clone: ITEM-1 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-9019 Cat. No. Size 14-9019-80 25 ug 14-9019-82 100 ug Description: The ITEM-1 mAb reacts with human TWEAK Receptor/Fn14 (fibroblast growth factor-inducible 14 kDa protein). Fn14 is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region. Fn14 plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis. TWEAK-induced cell death via Fn14 includes both apoptosis and necrosis and can be blocked by an anti-TWEAK antibody, CARL-1. Fn14 is expressed on HUVEC and in some cancer tissues but not on freshly isolated PBMCs. Fn14 mRNA expression has been identified during liver regeneration.
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