產(chǎn)品名稱：Recombinant Human BAFF, 25 ug 產(chǎn)品貨號：eBioscience 14-8943-80 產(chǎn)品規(guī)格：25 ug Human CD257 (BAFF, BLyS) Recombinant Protein Also known as: TNFSF13B, BLYS, TALL-1, TALL1, THANK, B-cell activating factor RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-8943 Cat. No. Size 14-8943-62 5 ug 14-8943-80 25 ug Description: Recombinant human BAFF (B-cell activating factor), also referred to as BlyS, is a type II transmembrane protein of the TNF superfamily. BAFF is found on T cells, macrophages and dendritic cells. BAFF contains a cytoplasmic domain, transmembrane domain and extracellular domain which can be cleaved between amino acid 133 and 134 to produce a soluble form detectable in serum. Receptors for BAFF include TACI, BAMBI and BAFFR. BAFF/BLyS is a B lymphocyte stimulatory molecule; it induces B cell proliferation and immunoglobulin secretion. In addition BAFF can provide a co-stimulation signal to T lymphocytes. Elevated levels of BAFF has been implicated in the pathogenesis of some autoimmune diseases (particularly) B cell diseases such as systemic lupus erythaematosus. Human and mouse BAFF share 86% amino acid sequence identity.
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