產(chǎn)品名稱：Human NT-3 Recombinant Protein 25 ug 產(chǎn)品貨號：eBioscience 14-8939-80 產(chǎn)品規(guī)格：25 ug Human Neurotrophin (NT-3) Recombinant Protein Also known as: Neurotrophin-3, NT-3, HDNF, Nerve growth factor 2, NGF-2, Neurotrophic factor RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-8939 Cat. No. Size 14-8939-62 5 ug 14-8939-80 25 ug Description: Neurotrophin-3 (NT-3) is a member of the neurotrophic growth factor family that also includes NGF, NT-4/5, and BDNF. These factors are important for the development and survival of neurons in the central and peripheral nervous system, and each family member targets different, but partially overlapping, subsets of neurons. NT-3 is responsible for the survival of proprioceptive and mechanoreceptive sensory neurons, and is expressed primarily by skeletal muscle and the central nervous system. It preferentially activates the TrkC receptor, but can also react with the receptors for the other members of the family, TrkA and TrkB, as well as with the lower-affinity p75 receptor. Binding of NT-3 to TrkC transmits a survival signal to the target cell, while in the absence of NT-3, TrkC signaling results in apoptosis.
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