產(chǎn)品名稱：Anti-Human TRA-1-60 (Podocalyxin) Purified TRA-1-60 100 ug 產(chǎn)品貨號：eBioscience 14-8863-82 產(chǎn)品規(guī)格：100 ug Anti-Human TRA-1-60 (Podocalyxin) Purified Also known as: TRA1-60, podocalyxin Clone: TRA-1-60 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-8863 Cat. No. Size 14-8863-80 25 ug 14-8863-82 100 ug Description: The TRA-1-60 antibody recognizes a protein expressed on undifferentiated human embryonic stem cells (ES), embyronal carcinoma cells (EC), and embryonic germ cells (EG). Like other stem cell specific markers, the epitope recognized by the TRA-1-60 antibody is lost upon cell differentiation. Contrary to early reports that the TRA-1-60 epitope can be destroyed by neuraminidase digestion, new strudies have shown that TRA-1-60 recognizes a neurominidase resistent antigen. The TRA-1-60 antibody is known to specifically recognize a carbohydrate epitope on a keratan sulfated glycoprotein recently identified as podocalyxin, a member of the CD34-related family of sialomucins. Podocalyxin is a transmembrane glycoprotein originally identified on epithelial glomerular cells known as podocytes, and the protein has also been implicated in the development of aggressiveness in a variety of cancers, including breast and prostate cancer.
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