產品名稱：anti-mouse IL-23 (p19) Purified 5B2 500 ug 產品貨號：eBioscience 14-7233-85 產品規(guī)格：500 ug Anti-Mouse IL-23 p19 Purified Also known as: Interleukin-23, p40, p19 Clone: 5B2 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-7233 Cat. No. Size 14-7233-81 50 ug 14-7233-85 500 ug Description: The 5B2 antibody reacts with the p19 subunit of mouse IL-23. The 5B2 antibody in combination with the C17.8 antibody yields an improved IL-23 sandwich ELISA with greater sensitivity than was achievable with previous assays. The 5B2 antibody is a non-neutralizing antibody. IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 disulfide-linked with a protein p19. p19, like p35 of IL-12, is biologically inactive by itself. IL-23 interacts with IL-12Rbeta1 and an additional, novel beta2-like receptor subunit with STAT4 binding domain, termed IL-23R. IL-23 is secreted by activated mouse and human dendritic cells. Biological activities of mouse IL-23 are distinct from those of mouse IL-12. Mouse IL-23 was found not to induce significant amounts of IFN gamma. Mouse IL-23 does induce strong proliferation of memory T cells (but not naïve T cells), whereas IL-12 has no effect on memory cells. Additionally, mouse IL-23 (but not IL-12) can activate mouse memory T cells to produce the proinflammatory cytokine IL-17. Human IL-23 has biological properties which are less distinct from human IL-12; human IL-23 induces proliferation of memory T cells and induces moderate levels of IFN gamma production by naïve and memory T cells, as compared to IL-12.
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