產(chǎn)品名稱：Anti-Mouse IL-12 p35 Purified (C18.2) 500 ug 產(chǎn)品貨號：eBioscience 14-7122-85 產(chǎn)品規(guī)格：500 ug Anti-Mouse IL-12 p35 Purified Also known as: Interleukin-12 Clone: C18.2 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-7122 Cat. No. Size 14-7122-81 50 ug 14-7122-85 500 ug Description: The C18.2 antibody reacts with the p35 subunit of mouse interleukin-12 (IL-12). The C18.2 antibody is a non-neutralizing antibody. Interleukin-12 (IL-12) is a heterodimeric 70 kD (p70) cytokine composed of two covalently linked, glycosylated chains, 40kD (p40) and 35-kD (p35). IL-12 is mainly produced by monocytes, macrophages, and dendritic cells in response to bacterial products such as lipopolysaccharides (LPS), to intracellular pathogens or upon interaction with activated T cells. IL-12 was originally discovered because of its ability to induce interferon-gamma (IFN-g) production, cell proliferation, and cytotoxicity mediated by natural killer cells and T cells. It is now established that IL-12 also plays a key role in the development of Th1 responses, leading to IFN-g and IL-2 production. These cytokines can in turn promote T-cell responses and macrophage activation.
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