產品名稱：Anti-Human CD254 (RANKL) Purified (MIH24) 100 ug 產品貨號：eBioscience 14-6619-82 產品規(guī)格：100 ug Anti-Human CD254 (RANK Ligand) Purified Also known as: TRANCE, OPGL, RANKL Clone: MIH24 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-6619 Cat. No. Size 14-6619-80 25 ug 14-6619-82 100 ug Description: The MIH24 monoclonal antibody reacts with human TRANCE (TNF-related activation-induced cytokine receptor) also known as RANKL (receptor activator of NF-κB ligand) and OPGL (Osteoprotegerin Ligand). TRANCE is a type II membrane protein with predicted molecular weight of 35 kDa. Its extracellular domain is most closely related to TRAIL, FasL and TNF. TRANCE mRNA is upregulated by TCR stimulation. TRANCE-deficient mouse lacks osteoclasts. In addition, TRANCE has been shown to be involved in the interactions between T-dendritic and T-B cells. It was also found to be critical in osteoclast differentiation. The TRANCE-RANK interaction regulates the expression of the anti-apoptotic molecule Bcl-xL.
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