產(chǎn)品名稱：Anti-Human PDX1 Purified (2A12) 100 ug 產(chǎn)品貨號(hào)：eBioscience 14-6500-82 產(chǎn)品規(guī)格：100 ug Anti-Human PDX1 Purified Also known as: Pancreatic and duodenal homeobox protein, insulin promoter factor 1 Clone: 2A12 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-6500 Cat. No. Size 14-6500-80 25 ug 14-6500-82 100 ug Description: This 2A12 monoclonal antibody reacts with the transcriptional activator PDX1, also known as pancreatic and duodenal homeobox protein and insulin promoter factor. Early expression of PDX1 during development marks the endoderm from which the pancreas, stomach, and duodenum derive. In the mature pancreas, expression is found in insulin-expressing beta-cells. PDX1 functions as an important regulator of several key pancreatic proteins including insulin, somatostatin, glucokinase, islet amyloid factor, and glucose transporter type 2. Deficiency in PDX1 results in a dysregulation of the beta-cell compensation of insulin resistance, which can lead to late-onset type 2 diabetes mellitus (formerly NIDDM) and maturity onset diabetes of the young type 4 (MODY4).
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