產(chǎn)品名稱：anti-human MyD88 Purified Polyclonal 50 ug 產(chǎn)品貨號：eBioscience 14-6222-81 產(chǎn)品規(guī)格：50 ug Anti-Human MyD88 Purified Also known as: Myeloid differentiation primary response protein MyD88 Clone: Polyclonal RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-6222 Cat. No. Size 14-6222-63 10 ug 14-6222-81 50 ug Description: The polyclonal antibody reacts with human MyD88; the antibody was raised against residues 233-248 of human MyD88 and recognizes human antigens. MyD88, a myeloid differentiation primary response gene, is expressed in a variety of tissues and functions as an adapter molecule in the IL-1 signaling pathway involved in the inflammatory responses induced by cytokines and LPS. MyD88 associates with and recruits IRAK to the IL-1 receptor. Dominant negative mutants of MyD88 attenuate IL-1R-mediated NF-κB activation. MyD88 also functions as a regulator molecule for IL-18 receptor and human Toll receptor family. Targeted disruption of the MyD88 gene results in loss of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to LPS. For applications with mouse MyD88, it is recommended that anti-human/mouse MyD88 (C-terminus) (cat. 14-6223) be used.
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